Model selection via Bayesian information capacity designs for generalised linear models

The first investigation is made of designs for screening experiments where the response variable is approximated by a generalised linear model. A Bayesian information capacity criterion is defined for the selection of designs that are robust to the form of the linear predictor. For binomial data and logistic regression, the effectiveness of these designs for screening is assessed through simulation studies using all-subsets regression and model selection via maximum penalised likelihood and a generalised information criterion. For Poisson data and log-linear regression, similar assessments are made using maximum likelihood and the Akaike information criterion for minimally-supported designs that are constructed analytically. The results show that effective screening, that is, high power with moderate type I error rate and false discovery rate, can be achieved through suitable choices for the number of design support points and experiment size. Logistic regression is shown to present a more challenging problem than log-linear regression. Some areas for future work are also indicated

Tent construction and use by Uroderma bilobatum in coconut palms (Cocos nucifera) in Costa Rica

Tent construction and use, uniformity of tents, and frond selection were studied in a population of Uroderma bilobatum roosting in coconut palms (Cocos nucifera) in Parque Nacional Palo Verde, Guanacaste Province, northwestern Costa Rica during July 1988. Palm leaflets were cut at their midribs in a line converging distally with the frond midrib, and the leaflets collapsed downward to form a large enclosed tent. Tent height, number of leaflets cut, and angle between the line of cut leaflets and the midrib of the fronds were measured to assess uniformity of tent construction. To ascertain if bats were selecting specific trees or fronds, we measured the angle of orientation of cut fronds, number of fronds hanging above a tent, and tree height. Bat tents were found in palms with a narrower range of heights than the overall tree population, and trees with tents were taller on average than trees without tents. A single altered frond provides excellent protection from rainfall. Bats do not seem to prefer fronds based on number of overhanging fronds or angle of orientation. The age of the modified frond may be an important factor in roost site selection, as tents in younger fronds were more likely to be occupied that those in older fronds. The number of bats roosting under tents ranged from 1 to 15 adults and subadults. The colony was composed largely of adult females and two age classes of young

Occupational Therapy and Accessibility in the Outdoors and Summer Camps

Opportunities for positive youth development (PYD) are promoted through both outdoor and camp experiences. The experiences provided by the outdoors and camps are ideal for developing physically, cognitively, socially, emotionally, and spiritually. These areas of PYD are further generalizable to several aspects of occupational performance and participation, while continuing to have benefits throughout the lifespan. While the outdoors and camps provide these valuable opportunities for development, the environments and contexts of these opportunities are often limiting factors for individuals with disabilities. Utilizing an occupational therapy approach allows for further understanding of how to promote inclusion and accessibility practices in these settings and further support occupational performance and participation for individuals of all abilities. The application of an occupational therapy perspective combined with research, review, and collaboration within these communities determined appropriate project objectives to address these areas of need. Further development based on project objectives led to the creation of Access Outdoors Occupational Therapy and the associated website www.accessoutdoorsot.com. Access Outdoors Occupational Therapy is a cumulative result of fulfilling project objectives and aims to promote and advocate for inclusion and accessibility in the outdoors and camp programs while also expanding available knowledge. Areas of growth for Access Outdoors Occupational Therapy include expanding occupational therapy roles, community partnerships, on the ground advocacy and outreach, and individualized consulting for outdoors and camp programs.https://soar.usa.edu/otdcapstonessummer2020/1001/thumbnail.jp

Mobilizing Students and Community Partners to Enhance the Health of the Rural Elderly

The Health Enhancement of the Rural Elderly (HERE) project is a federally funded grant project designed to empower the rural elderly in Butler and Edmonson counties to maximize their use of the health care system. This project was developed after identifying the needs of approximately 25% of the population in the U.S. that reside in rural areas. Of this population in rural Kentucky, 14-15% is 65 years or older (U.S. Bureau of Census, 2000). A higher incidence of chronic diseases, disabilities, difficulties with daily living activities, and cutbacks in social services have been identified as factors causing this population to be compromised in their success with health care

Electrolyte supplementation during severe energy restriction increases exercise capacity in the heat

PURPOSE. This study examined the effects of sodium chloride and potassium chloride supplementation during 48-h severe energy restriction on exercise capacity in the heat. METHODS. Nine males completed three 48-h trials: adequate energy intake (100 % requirement), adequate electrolyte intake (CON); restricted energy intake (33 % requirement), adequate electrolyte intake (ER-E); and restricted energy intake (33 % requirement), restricted electrolyte intake (ER-P). At 48 h, cycling exercise capacity at 60 % V˙V˙O2 peak was determined in the heat (35.2 °C; 61.5 % relative humidity). RESULTS. Body mass loss during the 48 h was greater during ER-P [2.16 (0.36) kg] than ER-E [1.43 (0.47) kg; P < 0.01] and CON [0.39 (0.68) kg; P < 0.001], as well as greater during ER-E than CON (P < 0.01). Plasma volume decreased during ER-P (P < 0.001), but not ER-E or CON. Exercise capacity was greater during CON [73.6 (13.5) min] and ER-E [67.0 (17.2) min] than ER-P [56.5 (13.1) min; P < 0.01], but was not different between CON and ER-E (P = 0.237). Heart rate during exercise was lower during CON and ER-E than ER-P (P < 0.05). CONCLUSIONS. These results demonstrate that supplementation of sodium chloride and potassium chloride during energy restriction attenuated the reduction in exercise capacity that occurred with energy restriction alone. Supplementation maintained plasma volume at pre-trial levels and consequently prevented the increased heart rate observed with energy restriction alone. These results suggest that water and electrolyte imbalances associated with dietary energy and electrolyte restriction might contribute to reduced exercise capacity in the heat

Developing a conversation: A strategy to engage faculty in pedagogical change

Personal interviews were conducted with biochemistry faculty during which they were presented with student performances on a content survey. From these interviews, four themes that reflect faculty responses to the surveys emerged: awareness of student understanding, self reflection on teaching practice, planned collaboration with colleagues, and emotional reactions. Here, we discuss these themes and their implications for creating conversation designed to promote reflection on biochemistry teaching

Composition for detecting uranyl

The present invention relates to an indicator composition for use in spectrophotometric detection of a substance in a solution, and a method for making the composition. Useful indicators are sensitive to the particular substance being measured, but are unaffected by the fluid and other chemical species that may be present in the fluid. Optical indicators are used to measure the uranium concentration of process solutions in facilities for extracting uranium from ores, production of nuclear fuels, and reprocessing of irradiated fuels. The composition comprises an organohalide covalently bonded to an indicator for the substance, in such a manner that the product is itself an indicator that provides increased spectral resolution for detecting the substance. The indicator is preferably arsenazo III and the organohalide is preferably cyanuric chloride. These form a composition that is ideally suited for detecting uranyl

QHREDGS Enhances Tube Formation, Metabolism and Survival of Endothelial Cells in Collagen-Chitosan Hydrogels

Cell survival in complex, vascularized tissues, has been implicated as a major bottleneck in advancement of therapies based on cardiac tissue engineering. This limitation motivates the search for small, inexpensive molecules that would simultaneously be cardio-protective and vasculogenic. Here, we present peptide sequence QHREDGS, based upon the fibrinogen-like domain of angiopoietin-1, as a prime candidate molecule. We demonstrated previously that QHREDGS improved cardiomyocyte metabolism and mitigated serum starved apoptosis. In this paper we further demonstrate the potency of QHREDGS in its ability to enhance endothelial cell survival, metabolism and tube formation. When endothelial cells were exposed to the soluble form of QHREDGS, improvements in endothelial cell barrier functionality, nitric oxide production and cell metabolism (ATP levels) in serum starved conditions were found. The functionality of the peptide was then examined when conjugated to collagen-chitosan hydrogel, a potential carrier for in vivo application. The presence of the peptide in the hydrogel mitigated paclitaxel induced apoptosis of endothelial cells in a dose dependent manner. Furthermore, the peptide modified hydrogels stimulated tube-like structure formation of encapsulated endothelial cells. When integrin αvβ3 or α5β1were antibody blocked during cell encapsulation in peptide modified hydrogels, tube formation was abolished. Therefore, the dual protective nature of the novel peptide QHREDGS may position this peptide as an appealing augmentation for collagen-chitosan hydrogels that could be used for biomaterial delivered cell therapies in the settings of myocardial infarction